P2517 - Biotech Development Senior Scientist (ADCs)

We are currently looking for a motivated and collaborative professional to join our Pharmaceutical Development Department based at our Headquarters in Lausanne, Switzerland as

Biotech Development Senior Scientist (ADCs)

Under the responsibility of the Biotech Development Manager, the role brings a strong technical expertise to the Pharmaceutical Development Department for the supply of biological active compounds.

The Biotech Development Senior Scientist participates in matrix-based teams with a strong spirit of collaboration. The role contributes to further develop the ADC platform (such as antibody humanization, antibody optimization, developability assessment, process development-) and to establish strategies for multi-specific antibodies for therapeutic development. The Biotech Development Senior Scientist has a deep understanding of the competitive landscape and the technologies used to develop biological assets for oncology. The role also coordinates and oversees technical and GMP activities managed by selected CDMOs.

Your Mission.

• Act as CMC Project Lead and Subject Matter Expert (SME) for Antibody Drug Conjugate (ADC) projects.
• Lead, plan, and manage the development of biological active compounds, tech transfer, scale up, as well as GMP manufacturing to supply clinical material for Phase I to phase III.
• Plan, execute, and document the design, early production, and characterization of monoclonal, bispecific, and new antibody constructs intended for the ADC constructs.
• Participate as an antibody engineering expert in multiple project teams for assets at different stages of the discovery process.
• Actively participate in early development teams and CMC project teams for the antibody developability assessment (primary sequence analysis, binding analysis, etc.). Identify strategies to construct new bispecific antibodies and new antibody formats.
• Propose optimization of antibody production and purification by improving solubility, stability, and expression yield using rational design.
• Monitor new antibody-based technologies, innovations and competitors.
• Participate in vendor selection for the production of antibodies and derivatives from R&D scale to GMP scale
• Collaborate in intellectual property searches and support in patent drafting linked to antibodies and ADCs. Explore patent literature to identify known antibody sequences against targets of interest.
• Support our Search & Evaluation team to evaluate potential new assets.

More than a checklist of skills, we-re looking for someone who shares our commitment to science with purpose.

• PhD or Engineering degree with at least 7 years- experience in Biotech environment;
• Proven experience in cross-functional program management including as a CMC Project Lead;
• SME experience in Biotech, with hands-on expertise in ADC development;
• Knowledge in antibody engineering, in protein structure, and homology modelling;
• Background in Molecular biology including cloning, primer design, mutagenesis, expression vector design, and sequence analysis;
• Experience in developability assessment for antibodies and ADC;
• Comprehensive understanding of the global development of biologicals from R&D to late-stage clinical development;
• Comprehensive understanding of regulatory aspects for biotech products;
• Experience in CRO / CDMO management;
• Creative mindset, problem solving, and results oriented;
• Strong communication, team spirit, and organizational skills;
• English fluent spoken and written is mandatory - French a plus.
• Being part of a company where innovation, collaboration, and impact aren-t just values - they-re how we work every day
• Partner with teams across disciplines, at the forefront of oncology and anti-infective development
• An inclusive and respectful workplace - proud to be Equal-Pay certified
• Grow in a culture that values people, purpose, and performance
• A chance to grow, share, and shape the future of healthcare

What to Expect in the Recruitment Process:

If your application is selected, you-ll be invited to interviews with Talent Acquisition and the Hiring Manager via Teams, followed by a panel interview and reference checks. Communication is handled via Workable-check your spam folder for emails from *@outbound.workable.com.

Please contact our HR Department prior to submitting any profiles. We cannot accept unsolicited applications from agencies or recruiters.